<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-12-23</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001849011</issuerCik>
        <issuerName>Apeiron Capital Investment Corp.</issuerName>
        <issuerTradingSymbol>APN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001451531</rptOwnerCik>
            <rptOwnerName>SPRING CREEK CAPITAL LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>4111 E. 37TH STREET NORTH</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WICHITA</rptOwnerCity>
            <rptOwnerState>KS</rptOwnerState>
            <rptOwnerZipCode>67220</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000923338</rptOwnerCik>
            <rptOwnerName>KOCH INDUSTRIES INC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>4111 E. 37TH STREET NORTH</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WICHITA</rptOwnerCity>
            <rptOwnerState>KS</rptOwnerState>
            <rptOwnerZipCode>67220</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Class A common stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>200000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Spring Creek Capital, LLC (&quot;Spring Creek&quot;) is beneficially owned by SCC Holdings, LLC (&quot;SCC&quot;), SCC is beneficially owned by KIM, LLC (&quot;KIM&quot;), KIM is beneficially owned by Koch Investments Group, LLC (&quot;KIG&quot;), KIG is beneficially owned by Koch Investments Group Holdings, LLC (&quot;KIGH&quot;), KIGH is beneficially owned by Koch Industries, Inc. (&quot;Koch Industries&quot;), in each case by means of ownership of all voting equity instruments. Koch Industries, KIGH, KIG, KIM and SCC may be deemed to beneficially own the shares of Class A common stock of Apeiron Capital Investment Corp. (the &quot;Issuer&quot;) held by Spring Creek by virtue of (i) Koch Industries beneficial ownership of KIGH, (ii) KIGH's beneficial ownership of KIG, (iii) KIG's beneficial ownership of KIM, (iv) KIM's beneficial ownership of SCC and (v) SCC's beneficial ownership of Spring Creek.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Spring Creek Capital, LLC /s/ Raffaele G. Fazio, Vice President and Secretary</signatureName>
        <signatureDate>2023-01-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Koch Industries, Inc. /s/ Raffaele G. Fazio, Assistant Secretary</signatureName>
        <signatureDate>2023-01-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
