<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001451437</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000277135</issuerCik>
            <issuerName>W.W. Grainger, Inc.</issuerName>
            <secFileNumber>001-05684</secFileNumber>
            <issuerAddress>
                <ns2:street1>100 Grainger Parkway</ns2:street1>
                <ns2:city>Lake Forest</ns2:city>
                <ns2:stateOrCountry>IL</ns2:stateOrCountry>
                <ns2:zipCode>60045-5201</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>8475351000</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DONALD MACPHERSON</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>26686</noOfUnitsSold>
            <aggregateMarketValue>25916375.76</aggregateMarketValue>
            <noOfUnitsOutstanding>47549337</noOfUnitsOutstanding>
            <approxSaleDate>12/04/2025</approxSaleDate>
            <securitiesExchangeName>NYSE</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/04/2025</acquiredDate>
            <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>26686</amountOfSecuritiesAcquired>
            <paymentDate>12/04/2025</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <remarks>The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale.&#13;
</remarks>
        <noticeSignature>
            <noticeDate>12/04/2025</noticeDate>
            <planAdoptionDates>
                <planAdoptionDate>09/04/2025</planAdoptionDate>
            </planAdoptionDates>
            <signature>/s/ Donald G. Macpherson</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
