X0306 4 2020-10-28 0 0001503802 Karyopharm Therapeutics Inc. KPTI 0001451038 Lewis Tanya C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON MA 02459 0 1 0 0 EVP,Chief Reg.&Quality Officer Common Stock 2020-10-28 4 M 0 765 A 765 D Common Stock 2020-10-30 4 S 0 226 15.58 D 539 D Restricted Stock Units 2020-10-28 4 M 0 765 0.00 D Common Stock 765 2295 D Restricted stock units convert into Karyopharm Therapeutics Inc. common stock on a one-for-one basis. This transaction was a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units and does not represent a discretionary trade by the reporting person. On October 28, 2019, the reporting person was granted 3,060 restricted stock units, vesting in four equal annual installments beginning on the first anniversary of the grant date. 25% of the restricted stock units vested on October 28, 2020. Vested shares will be delivered to the reporting person as soon as practicable following the vesting date, but in any event within 30 days of such date. /s/Christopher B. Primiano, Attorney-in-Fact for Tanya Lewis 2020-11-04