X0306 4 2022-06-16 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001449008 Waksal Harlan C/O LYRA THERAPEUTICS, INC. 480 ARSENAL WAY WATERTOWN MA 02472 1 1 0 0 Executive Chair Stock Option 5.09 2022-06-16 4 A 0 953002 0.00 A 2032-06-15 Common Stock 953002 953002 D On June 16, 2022, the Reporting Person was granted an option to purchase 953,002 shares of common stock. The option vests and becomes exercisable as to 317,667 shares underlying the option when the Issuer's market capitalization reaches $250,000,000; (ii) 317,667 shares underlying the option when the Issuer's market capitalization reaches $350,000,000; and (iii) 317,668 shares underlying the option when the Issuer's market capitalization reaches $500,000,000, all subject to the Reporting Person's continued service to the Issuer through each such date. /s/ Jason Cavalier, Attorney-in-Fact for Harlan Waksal, M.D. 2022-06-21