X0306 4 2022-02-16 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001449008 Waksal Harlan C/O LYRA THERAPEUTICS, INC. 480 ARSENAL WAY WATERTOWN MA 02472 1 1 0 0 Executive Chair Stock Option 4.21 2022-02-16 4 A 0 520000 0.00 A 2032-02-15 Common Stock 520000 520000 D On February 16, 2022, the Reporting Person was granted an option to purchase 520,000 shares of common stock. The option vests and becomes exercisable as to 173,333 shares underlying the option when the Issuer's market capitalization reaches $250,000,000; (ii) 173,333 shares underlying the option when the Issuer's market capitalization reaches $350,000,000; and (iii) 173,334 shares underlying the option when the Issuer's market capitalization reaches $500,000,000, all subject to the Reporting Person's continued service to the Issuer through each such date. /s/ Jason Cavalier, Attorney-in-Fact for Harlan Waksal, M.D. 2022-02-18