X0306 4 2022-12-12 0001267565 COLLEGIUM PHARMACEUTICAL, INC COLL 0001448914 Heffernan Michael Thomas C/O COLLEGIUM PHARMACEUTICAL, INC. 100 TECHNOLOGY CENTER DRIVE STOUGHTON MA 02072 1 0 0 0 Common Stock 2022-12-12 4 M 0 10669 14.9 A 38692 D Common Stock 2022-12-12 4 M 0 15741 15.27 A 54433 D Common Stock 2022-12-12 4 M 0 1510 14.57 A 55943 D Common Stock 2022-12-12 4 S 0 27920 22.01 D 28023 D Common Stock 2022-12-13 4 M 0 59524 14.9 A 87547 D Common Stock 2022-12-13 4 M 0 94259 15.27 A 181806 D Common Stock 2022-12-13 4 M 0 7904 14.57 A 189710 D Common Stock 2022-12-13 4 S 0 161687 22.16 D 28023 D Stock Option (Right to Purchase) 14.9 2022-12-12 4 M 0 10669 0 D 2025-05-14 Common Stock 10669 0 D Stock Option (Right to Purchase)t to 15.27 2022-12-12 4 M 0 15741 0 D 2027-02-10 Common Stock 15741 0 D Stock Option (Right to Purchase) 14.570 2022-12-12 4 M 0 1510 0 D 2029-04-25 Common Stock 1510 0 D Stock Option (Right to Purchase) 14.9 2022-12-13 4 M 0 59524 0 D 2025-05-14 Common Stock 59524 0 D Stock Option (Right to Purchase) 15.27 2022-12-13 4 M 0 94259 0 D 2027-02-10 Common Stock 94259 0 D Stock Option (Right to Purchase) 14.57 2022-12-13 4 M 0 7904 0 D 2029-04-25 Common Stock 7904 0 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 10, 2022. The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.00 to $22.09, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote (2). The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.00 to $22.44, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote (3). All of the 10,669 option shares are exercisable. All of the 15,741 option shares are exercisable. All of the 1,510 option shares are exercisable. All of the 59,524 option shares are exercisable. All of the 94,259 option shares are exercisable. All of the 7,904 option shares are exercisable. /s/ Colleen Tupper as Attorney-In-Fact For Michael T. Heffernan 2022-12-14