<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Sachem Head Capital Management LP -->
          <cik>0001582090</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001447669</issuerCik>
      <issuerName>Twilio Inc.</issuerName>
      <secFileNumber>001-37806</secFileNumber>
      <issuerAddress>
        <com:street1>101 Spear Street, Fifth Floor</com:street1>
        <com:city>San Francisco</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94105</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>415-390-2337</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sachem Head Capital Management LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director, Affiliate of Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Cowen &amp; Company LLC</name>
        <address>
          <com:street1>599 Lexington Ave</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>675000</noOfUnitsSold>
      <aggregateMarketValue>130637745.00</aggregateMarketValue>
      <noOfUnitsOutstanding>151773860</noOfUnitsOutstanding>
      <approxSaleDate>05/12/2026</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/21/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Open market purchases</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>N/A</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>675000</amountOfSecuritiesAcquired>
      <paymentDate>02/21/2024</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Sachem Head Capital Management LP (SHCM) is the investment manager of certain funds that are selling the shares. Andrew Stafman, partner of SHCM, is a director of the Issuer. The aggregate market value is based on the sale price on 05/12/2026. The number of securities outstanding is as of 04/17/2026. The shares proposed to be sold were acquired and paid for between 02/21/2024 and 03/07/2024.</remarks>
    <noticeSignature>
      <noticeDate>05/12/2026</noticeDate>
      <signature>/s/ Michael Adamski, as General Counsel</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
