144 0001856565 XXXXXXXX LIVE 0001447362 CASTLE BIOSCIENCES INC 001-38984 1500 W. Parkwood Ave, Suite 400 Friendswood TX 77546 8667889007 KRISTEN OELSCHLAGER Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

4153 147556.09 30549507 10/01/2026 NASDAQ Common 10/01/2026 Exercise of Stock Options Issuer N 4153 10/01/2026 Cash N 10b5-1 Sales for KRISTEN OELSCHLAGER

1500 W. Parkwood Ave, Suite 400 Friendswood TX 77546

Common 09/01/2026 4152 138643.58 The Fritz Shorter Trust

1500 W. Parkwood Ave, Suite 400 Friendswood TX 77546

Common 08/25/2026 12384 426276.84 The Fritz Shorter Trust

1500 W. Parkwood Ave, Suite 400 Friendswood TX 77546

Common 08/24/2026 12218 411587.77 10b5-1 Sales for KRISTEN OELSCHLAGER

1500 W. Parkwood Ave, Suite 400 Friendswood TX 77546

Common 08/03/2026 8586 255633.70 10/01/2026 03/17/2026 /s/ Kristen Oelschlager