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Pay vs Performance Disclosure
Unit_pure in Thousands
 12 Months Ended
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Pay vs Performance Disclosure [Table]      
Pay vs Performance [Table Text Block]
Pay Versus Performance
We are required by SEC rules to disclose certain information regarding compensation paid to our NEOs. The amounts set forth below under the headings “Compensation Actually Paid to PEO” and “Average Compensation Actually Paid to
Non-PEO
NEOs” have been calculated in a manner consistent with Item 402(v) of Regulation
S-K.
Footnote (2) below sets forth the adjustments from the Total Compensation for each NEO reported in the Summary Compensation Table for the relevant year.
 
                                
Value of Initial Fixed $100
Investment Based on:
               
Year
(a)
   
Summary
Compensation
Table Total
for PEO
(1)
(b)
     
Compensation
Actually Paid
to PEO
(2)
(c)
     
Average
Summary
Compensation
Table Total for
Non-PEO

NEOs
(1)
(d)
     
Average
Compensation
Actually Paid
to
Non-PEO

NEOs
(2)
(e)
     
Total
Shareholder
Return
(3)
(f)
     
Peer Group
Total
Shareholder
Return
(3)
(g)
     
Net Loss
(4)
(in thousands)
(h)
    
Total
Revenue
(5)
(in thousands)
(i)
  
2022
    $ 7,552,577      $ 3,081,353      $ 2,670,395      $ 990,266      $ 68      $ 113      $ (67,138 )    $ 137,039  
2021
    $ 6,521,857      $ 2,127,860      $ 2,813,079      $ 1,240,785      $ 125      $ 125      $ (31,292 )    $ 94,085  
2020
    $ 5,344,639      $ 13,311,700      $ 1,953,619      $ 4,526,526      $ 195      $ 125      $ (10,284 )    $ 62,649  
 
(1)
Mr. Maetzold was our PEO for each of 2020, 2021 and 2022. In this disclosure, we refer to our NEOs other than Mr. Maetzold in any fiscal year as our “Other NEOs” or our
“Non-PEO
NEOs.” Frank Stokes, Kristen M. Oelschlager and Tobin W. Juvenal were “Other NEOs” for 2022 and 2021. Frank Stokes and Bernhard E. Spiess, our former Chief Business Officer, were the “Other NEOs” for 2020. The dollar amounts are the total compensation for the covered fiscal year as reported in the Summary Compensation Table pursuant to Regulation
S-K,
item 402(c)(2)(x), as described under “—Summary Compensation Table.” In the case of the Other NEOs, the amounts reported are an average of the total compensation for the covered fiscal years.
(2)
For each year, in determining both the compensation actually (“CAP”) for our PEO and the average CAP for our Other NEOs, we deducted or added back the following amounts from or to the total amounts of compensation reported in column (b) and column (d) for such year.
Mr. Maetzold’s CAP is calculated as follows:
 
Year
   
Total
Compensation
from Summary
Compensation
Table
     
Stock Awards
Value from
Summary
Compensation
Table
    
Option
Awards Value
from
Summary
Compensation
Table
    
Change in Fair
Value of
Awards
Vesting
During the
Year
    
Change in Fair
Value of
Outstanding and
Unvested Equity
Awards
    
Year-End Fair

Value of
Equity
Awards
Granted
During the
Year
     
Compensation
Actually Paid
  
2022
    $ 7,552,577      $ (6,102,902 )    $ —     $ (1,590,589 )    $ (3,085,629 )    $ 6,307,896      $ 3,081,353  
2021
    $ 6,521,857      $ (2,500,003 )    $ (2,656,954 )    $ (535,559 )    $ (4,200,151 )    $ 5,498,670      $ 2,127,860  
2020
    $ 5,344,639      $ (1,268,982 )    $ (3,056,657 )    $ 1,060,493     $ 6,181,735     $ 5,050,472      $ 13,311,700  
Other NEOs average CAP are as follows:
 
Year
   
Total
Compensation
from Summary
Compensation
Table
     
Stock Awards
Value from
Summary
Compensation
Table
    
Option
Awards Value
from
Summary
Compensation
Table
    
Change in Fair
Value of
Awards
Vesting
During the
Year
    
Change in Fair
Value of
Outstanding and
Unvested Equity
Awards
    
Year-End Fair

Value of
Equity Awards
Granted
During the
Year
     
Average
Compensation
Actually Paid
  
2022
    $ 2,670,395      $ (1,865,475 )    $ —     $ (549,674 )    $ (1,212,570 )    $ 1,947,590      $ 990,266  
2021
    $ 2,813,079      $ (999,993 )    $ (1,062,350 )    $ (215,497 )    $ (1,493,903 )    $ 2,199,449      $ 1,240,785  
2020
    $ 1,953,619      $ (414,120 )    $ (947,196 )    $ 332,321     $ 2,012,760     $ 1,589,142      $ 4,526,526  
 
(3)
For each fiscal year disclosed the cumulative total shareholder return and peer group cumulative total shareholder return is calculated in the same manner as Item 201(e) of Regulation
S-K
assuming an initial investment of $100 on December 31, 2019. The peer group used in this calculation is the NASDAQ Biotechnology Total Return Index.
(4)
The dollar amounts presented are from our consolidated financial statements appearing in our Annual Report on Form
10-K
for each of the reported fiscal years.
(5)
This is our Company-Selected Measure provided in accordance in with Item 402(v)(2)(vi) of Regulation
S-K.
The dollar amounts presented are from our consolidated financial statements appearing in our Annual Report on Form
10-K
for each of the reported fiscal years.
   
Company Selected Measure Name TotalRevenue    
Named Executive Officers, Footnote [Text Block] In this disclosure, we refer to our NEOs other than Mr. Maetzold in any fiscal year as our “Other NEOs” or our
“Non-PEO
NEOs.” Frank Stokes, Kristen M. Oelschlager and Tobin W. Juvenal were “Other NEOs” for 2022 and 2021. Frank Stokes and Bernhard E. Spiess, our former Chief Business Officer, were the “Other NEOs” for 2020. 		   
Peer Group Issuers, Footnote [Text Block] For each fiscal year disclosed the cumulative total shareholder return and peer group cumulative total shareholder return is calculated in the same manner as Item 201(e) of Regulation
S-K
assuming an initial investment of $100 on December 31, 2019. The peer group used in this calculation is the NASDAQ Biotechnology Total Return Index. 		   
PEO Total Compensation Amount $ 7,552,577 $ 6,521,857 $ 5,344,639
PEO Actually Paid Compensation Amount $ 3,081,353 2,127,860 13,311,700
Adjustment To PEO Compensation, Footnote [Text Block]
(2)
For each year, in determining both the compensation actually (“CAP”) for our PEO and the average CAP for our Other NEOs, we deducted or added back the following amounts from or to the total amounts of compensation reported in column (b) and column (d) for such year.
Mr. Maetzold’s CAP is calculated as follows:
 
Year
   
Total
Compensation
from Summary
Compensation
Table
     
Stock Awards
Value from
Summary
Compensation
Table
    
Option
Awards Value
from
Summary
Compensation
Table
    
Change in Fair
Value of
Awards
Vesting
During the
Year
    
Change in Fair
Value of
Outstanding and
Unvested Equity
Awards
    
Year-End Fair

Value of
Equity
Awards
Granted
During the
Year
     
Compensation
Actually Paid
  
2022
    $ 7,552,577      $ (6,102,902 )    $ —     $ (1,590,589 )    $ (3,085,629 )    $ 6,307,896      $ 3,081,353  
2021
    $ 6,521,857      $ (2,500,003 )    $ (2,656,954 )    $ (535,559 )    $ (4,200,151 )    $ 5,498,670      $ 2,127,860  
2020
    $ 5,344,639      $ (1,268,982 )    $ (3,056,657 )    $ 1,060,493     $ 6,181,735     $ 5,050,472      $ 13,311,700  
    
Non-PEO NEO Average Total Compensation Amount $ 2,670,395 2,813,079 1,953,619
Non-PEO NEO Average Compensation Actually Paid Amount $ 990,266 1,240,785 4,526,526
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Other NEOs average CAP are as follows:
 
Year
   
Total
Compensation
from Summary
Compensation
Table
     
Stock Awards
Value from
Summary
Compensation
Table
    
Option
Awards Value
from
Summary
Compensation
Table
    
Change in Fair
Value of
Awards
Vesting
During the
Year
    
Change in Fair
Value of
Outstanding and
Unvested Equity
Awards
    
Year-End Fair

Value of
Equity Awards
Granted
During the
Year
     
Average
Compensation
Actually Paid
  
2022
    $ 2,670,395      $ (1,865,475 )    $ —     $ (549,674 )    $ (1,212,570 )    $ 1,947,590      $ 990,266  
2021
    $ 2,813,079      $ (999,993 )    $ (1,062,350 )    $ (215,497 )    $ (1,493,903 )    $ 2,199,449      $ 1,240,785  
2020
    $ 1,953,619      $ (414,120 )    $ (947,196 )    $ 332,321     $ 2,012,760     $ 1,589,142      $ 4,526,526  
    
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
The following chart shows the relationships between (a) the compensation actually paid to the PEO, (b) the average compensation actually paid to the
Non-PEO
NEOs included in the Summary Compensation Table and (c) our total shareholder return and the peer group total shareholder return.
 
LOGO
 
    
Compensation Actually Paid vs. Net Income [Text Block]
The following chart shows the relationships between (a) the compensation actually paid to the PEO, (b) the average compensation actually paid to the
Non-PEO
NEOs in the Summary Compensation Table and (c) our net loss.
 
LOGO
   
Compensation Actually Paid vs. Company Selected Measure [Text Block]
The following chart shows the relationships between (a) the compensation actually paid to the PEO, (b) the average compensation actually paid to the
Non-PEO
NEOs included in the Summary Compensation Table and (c) our company-selected measure of total revenue.
 
LOGO
   
Total Shareholder Return Vs Peer Group [Text Block]
The following chart shows the relationships between (a) the compensation actually paid to the PEO, (b) the average compensation actually paid to the
Non-PEO
NEOs included in the Summary Compensation Table and (c) our total shareholder return and the peer group total shareholder return.
 
LOGO
 
    
Tabular List [Table Text Block]
The following performance measures are the Company’s most important performance measures used by us to link compensation actually paid to our NEOs for the
year-end
December 31, 2022:
 
Metric
Financial Performance Metric:
Revenue
Non-financial
Performance Metrics:
Delivered Test Reports
Reimbursement Rates for our Tests
Positive Coverage Decisions for our Tests
Pipeline Milestones
    
Total Shareholder Return Amount $ 68 125 195
Peer Group Total Shareholder Return Amount 113 125 125
Net Income (Loss) $ (67,138,000) $ (31,292,000) $ (10,284,000)
Company Selected Measure Amount 137,039 94,085 62,649
PEO Name Mr. Maetzold    
Measure [Axis]: 1      
Pay vs Performance Disclosure [Table]      
Measure Name Revenue    
Measure [Axis]: 2      
Pay vs Performance Disclosure [Table]      
Measure Name Delivered Test Reports    
Measure [Axis]: 3      
Pay vs Performance Disclosure [Table]      
Measure Name Reimbursement Rates for our Tests    
Measure [Axis]: 4      
Pay vs Performance Disclosure [Table]      
Measure Name Positive Coverage Decisions for our Tests    
Measure [Axis]: 5      
Pay vs Performance Disclosure [Table]      
Measure Name Pipeline Milestones    
PEO [Member] | Stock Awards Value [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount $ (6,102,902) $ (2,500,003) $ (1,268,982)
PEO [Member] | Option Awards Value [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount 0 (2,656,954) (3,056,657)
PEO [Member] | Change In Fair Value Of Awards Vesting During The Year [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount (1,590,589) (535,559) 1,060,493
PEO [Member] | Change In Fair Value Of Outstanding And Unvested Equity Awards [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount (3,085,629) (4,200,151) 6,181,735
PEO [Member] | Year End Fair Value Of Equity Awards Granted During The Year [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount 6,307,896 5,498,670 5,050,472
Non-PEO NEO [Member] | Stock Awards Value [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount (1,865,475) (999,993) (414,120)
Non-PEO NEO [Member] | Option Awards Value [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount 0 (1,062,350) (947,196)
Non-PEO NEO [Member] | Change In Fair Value Of Awards Vesting During The Year [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount (549,674) (215,497) 332,321
Non-PEO NEO [Member] | Change In Fair Value Of Outstanding And Unvested Equity Awards [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount (1,212,570) (1,493,903) 2,012,760
Non-PEO NEO [Member] | Year End Fair Value Of Equity Awards Granted During The Year [Member]      
Pay vs Performance Disclosure [Table]      
Adjustment to Compensation Amount $ 1,947,590 $ 2,199,449 $ 1,589,142