<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001635324</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001447028</issuerCik>
      <issuerName>Arbutus Biopharma Corp</issuerName>
      <secFileNumber>001-34949</secFileNumber>
      <issuerAddress>
        <com:street1>701 VETERANS CIRCLE</com:street1>
        <com:city>WARMINSTER</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>18974</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>604-419-3200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Sofia Michael J.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>245 Summer Street</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>100000</noOfUnitsSold>
      <aggregateMarketValue>338000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>189490000</noOfUnitsOutstanding>
      <approxSaleDate>03/13/2025</approxSaleDate>
      <securitiesExchangeName>nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>09/26/2012</acquiredDate>
      <natureOfAcquisitionTransaction>Merger Acquisition</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ABUS</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
      <paymentDate>09/26/2012</paymentDate>
      <natureOfPayment>Cash/Check</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Sofia c/o Arbutus Biopharma Corp</name>
        <address>
          <com:street1>701 VETERANS CIRCLE</com:street1>
          <com:city>WARMINSTER</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>18974</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/07/2025</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>33600.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Sofia c/o Arbutus Biopharma Corp</name>
        <address>
          <com:street1>701 VETERANS CIRCLE,</com:street1>
          <com:city>WARMINSTER</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>18974</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/11/2025</saleDate>
      <amountOfSecuritiesSold>157162</amountOfSecuritiesSold>
      <grossProceeds>481270.92</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>03/13/2025</noticeDate>
      <signature>/s/ Audrey Skillern as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Michael J. Sofia</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
