Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Revenue
Collaborations and contracts	$ 32	$ 2,310	$ 139	$ 5,830
Licensing fees, milestone and royalty payments	277	1,130	773	2,292
Total revenue	309	3,440	912	8,122
Expenses
Research, development, collaborations and contracts	15,215	9,690	28,359	20,247
General and administrative	23,766	7,662	30,985	10,378
Depreciation of property and equipment	252	147	469	267
Acquisition costs	0	361	0	9,656
Impairment of intangible assets	156,324	0	156,324	0
Total expenses	195,557	17,860	216,137	40,548
Loss from operations	(195,248)	(14,420)	(215,225)	(32,426)
Other income (losses)
Interest income	435	81	679	283
Foreign exchange gains (losses)	33	(2,571)	2,975	4,467
Gain on disposition of financial instrument	0	0	1,000	0
Decrease in fair value of warrant liability	168	2,024	329	801
Increase in fair value of contingent consideration	(252)	0	(496)	0
Total other income (losses)	384	(466)	4,487	5,551
Loss before income taxes	(194,864)	(14,886)	(210,738)	(26,875)
Income tax benefit	64,864	0	64,864	0
Net loss	$ (130,000)	$ (14,886)	$ (145,874)	$ (26,875)
Loss per common share
Loss per common share basic and diluted (in USD per share)	$ (2.47)	$ (0.27)	$ (2.80)	$ (0.64)
Weighted average number of common shares
Weighted average number of common shares basic and diluted (in shares)	52,716,059	54,255,804	52,052,165	42,297,517
Comprehensive loss
Cumulative translation adjustment	$ 0	$ 3,223	$ 0	$ (5,951)
Comprehensive loss	$ (130,000)	$ (11,663)	$ (145,874)	$ (32,826)