Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
Revenue
Revenues	$ 6,914	$ 6,011
Operating expenses
Research and development	47,481	57,601
General and administrative	14,724	17,727
Depreciation	1,978	2,028
Change in fair value of contingent consideration	473	(173)
Site consolidation	64	156
Impairment of intangible assets	0	43,836
Impairment of goodwill	0	22,471
Arbitration	0	6,266
Total operating expenses	64,720	149,912
Loss from operations	(57,806)	(143,901)
Other income (loss)
Interest income	741	2,111
Interest expense	(4,011)	(2,108)
Equity investment loss	(2,545)	(22,522)
Foreign exchange gain (loss)	(124)	41
Total other loss	(5,939)	(22,478)
Loss before income taxes	(63,745)	(166,379)
Income tax benefit	0	12,656
Net loss	(63,745)	(153,723)
Items applicable to preferred shares
Dividend accretion of convertible preferred shares	(12,123)	(11,149)
Net loss attributable to common shares	$ (75,868)	$ (164,872)
Loss per share
Basic and diluted (in USD per share)	$ (1.00)	$ (2.89)
Weighted average number of common shares
Basic and diluted (in shares)	75,835,378	57,093,454
Comprehensive income (loss)
Unrealized gain on available-for-sale securities	$ 14	$ 0
Currency translation adjustments	44	(59)
Comprehensive loss	(63,687)	(153,782)
Collaborations and licenses
Revenue
Revenues	3,519	4,355
Non-cash royalty revenue
Revenue
Revenues	$ 3,395	$ 1,656