Condensed Consolidated Statements of Cash Flow - USD ($) $ in Thousands	3 Months Ended		15 Months Ended
	Mar. 31, 2020	Mar. 31, 2019	Mar. 31, 2020
OPERATING ACTIVITIES
Net loss	$ (13,861)	$ (23,251)
Items not involving cash:
Depreciation	500	509
Gain on sale of property and equipment	0	(9)
Stock-based compensation expense	1,445	1,522
Unrealized foreign exchange losses (gains)	10	(38)
Change in fair value of contingent consideration	112	125
Net equity investment gain (loss)	0	4,651
Non-cash royalty revenue	(656)	(171)
Non-cash interest expense	1,039	0
Net accretion and amortization of investments in marketable securities	(2)	0
Net change in operating items:
Accounts receivable	132	777
Prepaid expenses and other assets	(439)	2,277
Accounts payable and accrued liabilities	(3,602)	(2,885)
Other liabilities	(131)	(87)
Net cash used in operating activities	(15,453)	(16,580)
INVESTING ACTIVITIES
Purchase of investments	(24,369)	(334)
Disposition of investments	21,968	61,389
Proceeds from sale of property and equipment	0	9
Acquisition of property and equipment	0	(31)
Net cash provided by / (used in) investing activities	(2,401)	61,033
FINANCING ACTIVITIES
Issuance of common shares pursuant to the Open Market Sale agreement	12,315	2,248
Issuance of common shares pursuant to exercise of options	166	288
Net cash provided by financing activities	12,481	2,536
Effect of foreign exchange rate changes on cash and cash equivalents	(10)	38
Increase / (decrease) in cash and cash equivalents	(5,383)	47,027
Cash and cash equivalents, beginning of period	31,799	36,942	$ 36,942
Cash and cash equivalents, end of period	26,416	83,969	$ 26,416
Non-cash transactions:
Preferred shares dividends accrued	$ (2,978)	$ (2,715)