Exhibit 31.1

CERTIFICATION PURSUANT TO RULE 13a-14 AND 15d-14 OF THE SECURITIES

EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF THE

SARBANES-OXLEY ACT OF 2002

I, William Collier, President and Chief Executive Officer of Arbutus Biopharma Corporation, certify that:

1. I have reviewed this Form 10-K/A;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

Date: March 6, 2020

	/s/ William Collier
Name:	William Collier
Title:	President and Chief Executive Officer
	(Principal Executive Officer)