144 0002061679 XXXXXXXX LIVE 0001446847 IRONWOOD PHARMACEUTICALS INC 001-34620 100 SUMMER STREET, SUITE 2300 BOSTON MA 02110 617-621-7722 Gaskins Tammi L Officer Class A Common Stock E Trade Securities LLC

3 Edison Drive Alpharetta GA 30005

1406 1237.28 161819848 08/11/2025 Nasdaq Class A Common Stock 08/16/2023 Restricted Stock Unit award granted pursuant to the Issuer's Amended and Restated 2019 Equity Incentive Plan, subject to vesting requirements Ironwood Pharmaceuticals, Inc. N 4000 08/16/2023 n/a N Tammi Gaskins

c/o Ironwood Pharmaceuticals, Inc. 100 Summer Street, Suite 2300 Boston MA 02110

Class A Common Stock 05/16/2025 2563 1486.54 Shares sold to cover taxes from the vesting of stock awards granted by the Issuer. 08/08/2025 /s/ Tammi Gaskins