144 0002053936 XXXXXXXX LIVE 0001446847 IRONWOOD PHARMACEUTICALS INC 001-34620 100 SUMMER STREET, SUITE 2300 BOSTON MA 02110 617-621-7722 Martini Gregory S. Officer Class A Common Stock E Trade Securities LLC

3 Edison Drive Alpharetta GA 30005

12347 23953.18 160028388 02/10/2025 Nasdaq Class A Common Stock 02/23/2021 Restricted Stock Unit award granted pursuant to the Issuer's 2019 Equity Incentive Plan, subject to vesting requirements Ironwood Pharmaceuticals, Inc. N 3250 02/23/2021 n/a Class A Common Stock 02/24/2022 Restricted Stock Unit award granted pursuant to the Issuer's 2019 Equity Incentive Plan, subject to vesting requirements Ironwood Pharmaceuticals, Inc. N 4242 02/24/2022 n/a Class A Common Stock 04/01/2022 Restricted Stock Unit award granted pursuant to the Issuer's 2019 Equity Incentive Plan, subject to vesting requirements Ironwood Pharmaceuticals, Inc. N 7500 04/01/2022 n/a Class A Common Stock 02/23/2023 Restricted Stock Unit award granted pursuant to the Issuer's 2019 Equity Incentive Plan, subject to vesting requirements Ironwood Pharmaceuticals, Inc. N 8905 02/23/2023 n/a Class A Common Stock 02/22/2024 Restricted Stock Unit award granted pursuant to the Issuer's Amended and Restated 2019 Equity Incentive Plan, subject to vesting requirements Ironwood Pharmaceuticals, Inc. N 6825 02/22/2024 n/a Y Shares sold to cover taxes from the vesting of stock awards granted by the Issuer. 02/07/2025 /s/ Gregory Martini