Collaboration, License, and Other Agreements - Japan (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2024	Sep. 30, 2024	Jun. 30, 2024	Mar. 31, 2024	Dec. 31, 2023	Sep. 30, 2023	Jun. 30, 2023	Mar. 31, 2023	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 90,545	$ 91,592	$ 94,396	$ 74,877	$ 117,553	$ 113,739	$ 107,382	$ 104,061	$ 351,410	$ 442,735	$ 410,596
Collaborative arrangements revenue
Collaboration, License, Promotion and Other Commercial Agreements
Revenue									351,410	442,735	410,596
Collaborative arrangement, collaboration and license agreements | Astellas Pharma Inc.
Collaboration, License, Promotion and Other Commercial Agreements
Revenue									1,673	1,799	2,001
Royalty | Astellas Pharma Inc., 2009 License Agreement, Amended 2019
Collaboration, License, Promotion and Other Commercial Agreements
Revenue									$ 1,700	$ 1,800	$ 2,000