Employee Stock Benefit Plans - Share-based Compensation Expense - Summary (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Employee Stock Benefit Plans
Share-based compensation expense	$ 7,067	$ 6,206	$ 19,757	$ 16,191
Research and development
Employee Stock Benefit Plans
Share-based compensation expense	1,316	1,258	3,607	3,635
Selling, general and administrative
Employee Stock Benefit Plans
Share-based compensation expense	$ 5,751	$ 4,948	$ 16,150	12,446
Restructuring expenses
Employee Stock Benefit Plans
Share-based compensation expense				$ 110