Collaboration, License, and Other Agreements - Japan (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 108,637	$ 103,747	$ 303,397	$ 296,623
Collaborative arrangements revenue
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	108,637	103,747	303,397	295,798
Collaborative arrangement, collaboration and license agreements | Astellas Pharma Inc.
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	520	555	1,543	1,621
Royalty | Astellas Pharma Inc., 2009 License Agreement, Amended 2019
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 500	$ 600	$ 1,500	1,600
Sale of active pharmaceutical ingredient
Collaboration, License, Promotion and Other Commercial Agreements
Revenue				$ 825