Employee Stock Benefit Plans - Share-based Compensation Expense - Summary (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Employee Stock Benefit Plans
Share-based compensation expense	$ 6,601	$ 4,589	$ 12,690	$ 9,985
Research and development
Employee Stock Benefit Plans
Share-based compensation expense	1,133	1,134	2,291	2,377
Selling, general and administrative
Employee Stock Benefit Plans
Share-based compensation expense	$ 5,468	$ 3,455	$ 10,399	7,498
Restructuring expenses
Employee Stock Benefit Plans
Share-based compensation expense				$ 110