Collaboration, License, and Other Agreements - Japan (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 97,231	$ 104,031	$ 194,760	$ 192,876
Collaborative arrangements revenue
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	97,231	103,386	194,760	192,051
Collaborative arrangement, collaboration and license agreements | Astellas Pharma Inc.
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	500	570	1,023	1,066
Royalty | Astellas Pharma Inc., 2009 License Agreement, Amended 2019
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 500	600	$ 1,000	1,100
Sale of active pharmaceutical ingredient
Collaboration, License, Promotion and Other Commercial Agreements
Revenue		$ 645		$ 825