Collaboration, License, and Other Agreements - North America - Commercial Efforts (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 97,231	$ 104,031	$ 194,760	$ 192,876
Selling, general and administrative	30,124	27,052	58,985	54,704
Collaborative arrangements revenue
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	97,231	103,386	194,760	192,051
Collaborative arrangements, LINZESS | AbbVie | U.S.
Collaboration, License, Promotion and Other Commercial Agreements
Selling, general and administrative	$ 8,500	$ 7,500	$ 17,200	$ 14,500