Collaboration, License, and Other Agreements - Japan (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 97,529	$ 88,845
Collaborative arrangements revenue
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	97,529	88,665
Collaborative arrangement, collaboration and license agreements | Astellas Pharma Inc.
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	523	496
Royalty | Astellas Pharma Inc., 2009 License Agreement, Amended 2019
Collaboration, License, Promotion and Other Commercial Agreements
Revenue	$ 500	500
Sale of active pharmaceutical ingredient
Collaboration, License, Promotion and Other Commercial Agreements
Revenue		$ 180