Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019
Cash flows from operating activities:
Net income (loss)	$ 28,549	$ (47,001)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Depreciation and amortization	1,322	1,539
Loss on disposal of property and equipment	423	109
Share-based compensation expense	13,455	20,271
Gain on lease modification		(3,169)
Change in fair value of note hedge warrants	(11,302)	16,428
Change in fair value of convertible note hedges	15,235	(19,700)
Non-cash interest expense	10,930	9,300
Changes in assets and liabilities:
Accounts receivable and related party accounts receivable, net	21,469	(21,529)
Prepaid expenses and other current assets	(3,638)	2,647
Inventory, net	648	(635)
Other assets	(30)	(6)
Accounts payable, related party accounts payable and accrued expenses	(13,861)	(25,205)
Accrued research and development costs	(556)	2,335
Operating lease right-of-use assets	587	6,315
Operating lease liabilities	593	(4,685)
Other liabilities	(133)
Net cash provided by (used in) continuing operating activities	63,691	(62,986)
Net cash provided by discontinued operating activities		11,364
Net cash provided by (used in) operating activities	63,691	(51,622)
Cash flows from investing activities:
Purchases of property and equipment	(1,814)	(1,444)
Proceeds from sale of property and equipment		261
Net cash used in continuing investing activities	(1,814)	(1,183)
Net cash used in discontinued investing activities		(4,223)
Net cash used in investing activities	(1,814)	(5,406)
Cash flows from financing activities:
Proceeds from exercise of stock options and employee stock purchase plan	14,352	5,204
Payments on 8.375% Notes due 2026		(21,469)
Net cash provided by (used in) continuing financing activities	14,352	(16,265)
Net cash provided by (used in) financing activities	14,352	(16,265)
Net increase (decrease) in cash, cash equivalents and restricted cash	76,229	(73,293)
Cash, cash equivalents and restricted cash, beginning of period	179,244	180,848
Cash, cash equivalents and restricted cash, end of period	$ 255,473	$ 107,555