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Collaboration, License, Co-Promotion and Other Commercial Agreements - Other Collaborations and License Agreements (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Collaboration, License and Co-Promotion Agreements        
Research and development $ 22,076 $ 28,758 $ 50,103 $ 60,956
Collaborative arrangement, co-promotion and other agreements | Development and sales milestones        
Collaboration, License and Co-Promotion Agreements        
Maximum payment receivable under the milestone 63,500   63,500  
Collaborative arrangement, other agreements        
Collaboration, License and Co-Promotion Agreements        
Revenue related to nonrefundable upfront payments   0   500
Research and development $ 0 $ 0 0 $ 0
Collaborative arrangement, other agreements | Regulatory milestones        
Collaboration, License and Co-Promotion Agreements        
Contingent milestone payable     18,000  
Milestone payment made     $ 0