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Collaboration, License, Co-Promotion and Other Commercial Agreements - North America - General Information (Details)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2020
USD ($)
Jun. 30, 2019
USD ($)
Jun. 30, 2020
USD ($)
item
payment
Jun. 30, 2019
USD ($)
Collaboration, License and Co-Promotion Agreements        
Research and development expense $ 22,076 $ 28,758 $ 50,103 $ 60,956
Sales milestones        
Collaboration, License and Co-Promotion Agreements        
Sales-related milestone if certain conditions are met 100,000   100,000  
AbbVie        
Collaboration, License and Co-Promotion Agreements        
Equity investment in the entity's capital stock     25,000  
Research and development expense 500   $ 1,200  
Net cost sharing offset or incremental expense related to research and development expense   2,400   5,600
Remaining commercial-period performance obligations | item     3  
AbbVie | Development and sales milestones        
Collaboration, License and Co-Promotion Agreements        
Cumulative license fees and development milestone payments received 205,000   $ 205,000  
AbbVie | Development milestones        
Collaboration, License and Co-Promotion Agreements        
Number of milestone payments received | payment     6  
AbbVie | Sales milestones        
Collaboration, License and Co-Promotion Agreements        
Percentage of net profit from commercialization (as a percent)     50.00%  
Percentage of net loss from commercialization (as a percent)     50.00%  
North America | AbbVie        
Collaboration, License and Co-Promotion Agreements        
Research and development expense $ 6,200 $ 9,600 $ 12,900 $ 19,600