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Collaboration, License, Co-Promotion and Other Commercial Agreements - Japan (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Aug. 01, 2019
USD ($)
Nov. 30, 2009
USD ($)
Mar. 31, 2020
USD ($)
Mar. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
payment
Dec. 31, 2016
USD ($)
Collaboration, License and Co-Promotion Agreements            
Revenue     $ 79,943 $ 68,730    
Astellas Pharma Inc. | Japan            
Collaboration, License and Co-Promotion Agreements            
Up-front fee received   $ 30,000        
Astellas Pharma Inc. | Japan | Additional development milestones            
Collaboration, License and Co-Promotion Agreements            
Number of milestone payments | payment         3  
Total milestone payments to be received         $ 45,000  
Collaborative arrangements revenue            
Collaboration, License and Co-Promotion Agreements            
Revenue     74,445 66,152    
Collaborative arrangement, collaboration and license agreements | Astellas Pharma Inc. | Japan            
Collaboration, License and Co-Promotion Agreements            
Revenue     479      
Revenue remaining performance obligation $ 20,400          
Non-refundable upfront payment $ 10,000          
Sale of active pharmaceutical ingredient            
Collaboration, License and Co-Promotion Agreements            
Revenue     5,498 2,578    
Sale of active pharmaceutical ingredient | Astellas Pharma Inc. | Japan            
Collaboration, License and Co-Promotion Agreements            
Revenue       2,575    
Revenue remaining performance obligation           $ 0
Sale of active pharmaceutical ingredient | Astellas Pharma Inc., 2009 License Agreement | Japan            
Collaboration, License and Co-Promotion Agreements            
Revenue       $ 2,600    
Royalty | Astellas Pharma Inc. | Japan            
Collaboration, License and Co-Promotion Agreements            
Revenue     $ 400