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Collaboration, License, Co-Promotion and Other Commercial Agreements - North America - General Information (Details)
$ in Thousands
3 Months Ended
Mar. 31, 2020
USD ($)
item
payment
Mar. 31, 2019
USD ($)
Collaboration, License and Co-Promotion Agreements    
Research and development expense $ 28,027 $ 32,198
Sales milestones    
Collaboration, License and Co-Promotion Agreements    
Sales-related milestone if certain conditions are met 100,000  
Allergan    
Collaboration, License and Co-Promotion Agreements    
Equity investment in the entity's capital stock 25,000  
Research and development expense 6,600 10,000
Net cost sharing offset or incremental expense related to research and development expense $ 800 $ 3,200
Remaining commercial-period performance obligations | item 3  
Allergan | Development and sales milestones    
Collaboration, License and Co-Promotion Agreements    
Cumulative license fees and development milestone payments received $ 205,000  
Allergan | Development milestones    
Collaboration, License and Co-Promotion Agreements    
Number of milestone payments received | payment 6  
Allergan | Sales milestones    
Collaboration, License and Co-Promotion Agreements    
Percentage of net profit from commercialization (as a percent) 50.00%  
Percentage of net loss from commercialization (as a percent) 50.00%