Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
Jun. 30, 2018	Jun. 30, 2017
Cash flows from operating activities:
Net loss	$ (92,524)	$ (96,725)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	3,461	4,838
Amortization of acquired intangible assets	6,952	841
(Gain) loss on disposal of property and equipment	(275)	135
Share-based compensation expense	19,794	16,419
Change in fair value of note hedge warrants	50,831	36,221
Change in fair value of convertible note hedges	(51,338)	(39,359)
Write-down of commercial supply and inventory to net realizable value and loss on non-cancellable purchase commitments	1,836	96
Write-down of excess non-cancellable ZURAMPIC and DUZALLO sample purchase commitments	390	1,353
Gain on facility subleases		(1,579)
Accretion of discount/premium on investment securities	(138)	111
Non-cash interest expense	8,591	7,849
Non-cash change in fair value of contingent consideration	2,474	8,547
Loss on extinguishment of debt		2,009
Changes in assets and liabilities:
Accounts receivable and related party accounts receivable	1,638	4,497
Prepaid expenses and other current assets	(9,373)	703
Inventory, net	(992)	1,081
Other assets	99	246
Accounts payable, related party accounts payable and accrued expenses	6,276	(5,345)
Accrued research and development costs	(1,935)	517
Deferred revenue		225
Deferred rent	656	(2,977)
Net cash used in operating activities	(53,577)	(60,297)
Cash flows from investing activities:
Purchases of available-for-sale securities	(2,491)	(90,706)
Sales and maturities of available-for-sale securities	62,512	251,027
Purchases of property and equipment	(3,200)	(1,746)
Proceeds from sale of property and equipment	272	79
Net cash provided by investing activities	57,093	158,654
Cash flows from financing activities:
Proceeds from issuance of 2026 Notes, net of discount to lender		146,250
Costs associated with issuance of 2026 Notes		(235)
Proceeds from exercise of stock options and employee stock purchase plan	19,044	18,473
Payments on capital leases	(1,510)	(1,593)
Principal payments on PhaRMA notes		(134,258)
Payments on contingent purchase price consideration	(121)	(56)
Net cash provided by financing activities	17,413	28,581
Net increase in cash, cash equivalents and restricted cash	20,929	126,938
Cash, cash equivalents and restricted cash, beginning of period	132,792	62,251
Cash, cash equivalents and restricted cash, end of period	153,721	189,189
Reconciliation of cash, cash equivalents, and restricted cash to the condensed consolidated balance sheets
Cash and cash equivalents	145,415	182,132
Restricted cash	8,306	7,057
Total Cash, cash equivalents, and restricted cash	$ 132,792	$ 62,251

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Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale.

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Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement.

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The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

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The cash outflow for the obligation for a lease meeting the criteria for capitalization (with maturities exceeding one year or beyond the operating cycle of the entity, if longer).

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The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer.

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Amount of cash and cash equivalents restricted as to withdrawal or usage. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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