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Collaboration, License, Co-Promotion and Other Commercial Agreements - European and Other Territories (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Oct. 31, 2015
Sep. 30, 2012
Collaboration, License and Co-Promotion Agreements            
Revenue $ 81,106 $ 65,077 $ 150,261 $ 117,243    
Allergan | Licensing agreement            
Collaboration, License and Co-Promotion Agreements            
Royalty percentage, five years following the first commercial sale     upper-single digits      
Annual royalty     5 years      
Royalty percentage, thereafter     low-double digits      
Royalty percentage, expanded territory     lower-single digits      
Allergan | Europe | Licensing agreement            
Collaboration, License and Co-Promotion Agreements            
Remaining milestone payment due upon the amendment to the license agreement         $ 42,500  
Collaborative arrangements            
Collaboration, License and Co-Promotion Agreements            
Revenue 71,207 58,640 $ 134,293 110,504    
Collaborative arrangements | Allergan | Europe | Licensing agreement            
Collaboration, License and Co-Promotion Agreements            
Revenue remaining performance obligation           $ 0
Royalty | Allergan | Europe | Licensing agreement            
Collaboration, License and Co-Promotion Agreements            
Revenue $ 300 $ 200 $ 600 $ 200