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Business Combinations - General Information (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Jun. 02, 2016
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2016
Business Combinations            
Payment for acquisition of lesinurad license         $ 100,000  
Lesinurad transaction            
Business Combinations            
Payment for acquisition of lesinurad license $ 100,000          
Lesinurad transaction | Scenario, Adjustment            
Business Combinations            
Net assets and liabilities     $ 0 $ 0    
Lesinurad transaction | AstraZeneca            
Business Combinations            
Payment for acquisition of lesinurad license 100,000          
Contingent consideration 67,885          
Acquisition related issuance costs   $ 1,600        
Net assets and liabilities 167,885          
Lesinurad transaction | AstraZeneca | Maximum            
Business Combinations            
Reimbursement obligation $ 100,000          
Licensing agreement | AstraZeneca            
Business Combinations            
Reimbursement obligation           $ 2,000
Period for reimbursement amount of development activities (in years) 10 years   10 years      
Royalty percentage per agreement       single digits    
Milestone payment to be paid by company upon milestone achievement       $ 165,000    
Licensing agreement | AstraZeneca | Maximum            
Business Combinations            
Reimbursement obligation     $ 100,000 $ 100,000    
Commercial Supply Agreement (CSA) | Lesinurad transaction | AstraZeneca            
Business Combinations            
Time period for manufacturing technology transfer per agreement 6 months