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Collaboration, License, Co-Promotion and Other Commercial Agreements - Other Collaborations and License Agreements (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Collaboration, License and Co-Promotion Agreements    
Research and development $ 33,702 $ 31,842
Agreement One - other collaboration and license agreements | Development milestones    
Collaboration, License and Co-Promotion Agreements    
Contingent milestone payable 7,500  
Milestone payment made 2,500  
Agreement One - other collaboration and license agreements | Regulatory milestones    
Collaboration, License and Co-Promotion Agreements    
Contingent milestone payable 18,000  
Milestone payment made 0  
Agreement Two - other collaboration and license agreements    
Collaboration, License and Co-Promotion Agreements    
Contingent milestone payable per product, maximum 114,500  
Agreement Two - other collaboration and license agreements | Sales milestones    
Collaboration, License and Co-Promotion Agreements    
Contingent milestone payable per product 35,000  
Agreement Two - other collaboration and license agreements | Development milestones    
Collaboration, License and Co-Promotion Agreements    
Contingent milestone payable per product 21,500  
Agreement Two - other collaboration and license agreements | Regulatory milestones    
Collaboration, License and Co-Promotion Agreements    
Contingent milestone payable per product $ 58,000