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Collaboration, License, Co-Promotion and Other Commercial Agreements - Japan (Details)
$ in Thousands
1 Months Ended 3 Months Ended
Nov. 30, 2009
USD ($)
Mar. 31, 2017
USD ($)
item
Mar. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
Collaboration, License and Co-Promotion Agreements        
Collaborative arrangements revenue   $ 51,877 $ 66,042  
Astellas | Collaborative arrangement        
Collaboration, License and Co-Promotion Agreements        
Collaborative arrangements revenue     14,700  
Deferred revenue related       $ 2,100
Astellas | Collaborative arrangement | Second development milestones        
Collaboration, License and Co-Promotion Agreements        
Collaborative arrangements revenue     12,900  
Astellas | Japan | Product related collaborative arrangements        
Collaboration, License and Co-Promotion Agreements        
Up-front fee received $ 30,000      
Up-front license fee revenue recognized     $ 1,300  
Astellas | Japan | Product related collaborative arrangements | Additional development milestones        
Collaboration, License and Co-Promotion Agreements        
Number of milestone payments to be received (in payments) | item   3    
Astellas | Japan | Product related collaborative arrangements | Additional development milestones | Maximum        
Collaboration, License and Co-Promotion Agreements        
Total milestone payments to be received   $ 45,000    
Astellas | Japan | Product related collaborative arrangements | Phase 3 milestones        
Collaboration, License and Co-Promotion Agreements        
Milestone payment to be received by company upon milestone achievement   15,000    
Astellas | Japan | Product related collaborative arrangements | Approval of Japanese NDA equivalent filing milestone        
Collaboration, License and Co-Promotion Agreements        
Milestone payment to be received by company upon milestone achievement   $ 15,000