Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Collaborative arrangements revenue	$ 51,877	$ 66,042
Product revenue, net	289
Total revenues	52,166	66,042
Cost and expenses:
Cost of revenues, excluding amortization of acquired intangible asset	531
Research and development	33,702	31,842
Selling, general and administrative	55,604	36,168
Amortization of acquired intangible asset	420
Loss on fair value remeasurement of contingent consideration	1,614
Total cost and expenses	91,871	68,010
Loss from operations	(39,705)	(1,968)
Other (expense) income:
Interest expense	(8,983)	(9,907)
Interest and investment income	395	221
Loss on derivatives	(2,199)	(1,643)
Loss on extinguishment of debt	(2,009)
Other expense, net	(12,796)	(11,329)
Net loss	$ (52,501)	$ (13,297)
Net loss per share - basic and diluted	$ (0.36)	$ (0.09)
Weighted average number of common shares used in net loss per share - basic and diluted:	147,786	143,593