Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Condensed Consolidated Statements of Operations
Collaborative arrangements revenue	$ 66,106	$ 39,572	$ 186,498	$ 96,248
Cost and expenses:
Cost of revenues, excluding amortization of acquired intangible asset				12
Write-down of inventory to net realizable value and loss on non-cancellable purchase commitments		9,488		17,638
Research and development	37,526	25,830	101,050	81,119
Selling, general and administrative	44,987	30,439	118,073	93,740
Amortization of acquired intangible asset	3,213		4,278
Loss on fair value remeasurement of contingent consideration	8,667		8,667
Total cost and expenses	94,393	65,757	232,068	192,509
Loss from operations	(28,287)	(26,185)	(45,570)	(96,261)
Other (expense) income:
Interest expense	(9,765)	(10,021)	(29,499)	(21,115)
Interest and investment income	307	156	823	292
Gain (loss) on derivatives	4,541	(11,340)	6,043	(11,548)
Other expense, net	(4,917)	(21,205)	(22,633)	(32,371)
Net loss	$ (33,204)	$ (47,390)	$ (68,203)	$ (128,632)
Net loss per share - basic and diluted	$ (0.23)	$ (0.33)	$ (0.47)	$ (0.91)
Weighted average number of common shares used in net loss per share - basic and diluted:	145,180	142,473	144,474	141,954