X0508 4 2023-11-20 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001932525 Davis Andrew C/O IRONWOOD PHARMACEUTICALS, INC. 100 SUMMER STREET, SUITE 2300 BOSTON MA 02110 0 1 0 0 SVP, Chief Business Officer 0 Class A Common Stock 2023-11-20 4 S 0 3287 9.69 D 217374 D The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person. The reporting person acquired 1,334 shares of Class A common stock under the issuer's employee stock purchase plan on June 30, 2023. /s/ Brian Tessler, Attorney-in-Fact 2023-11-22