X0407 4 2023-05-22 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001478448 MCCOURT Thomas A C/O IRONWOOD PHARMACEUTICALS, INC. 100 SUMMER STREET, SUITE 2300 BOSTON MA 02110 1 1 0 0 Chief Executive Officer 0 Class A Common Stock 2023-05-22 4 S 0 36000 10.12 D 784916 D The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person. /s/ Brian Tessler, Attorney-in-Fact 2023-05-24