X0306 4 2022-06-01 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001670893 Dreyfus Andrew C/O IRONWOOD PHARMACEUTICALS, INC. 100 SUMMER STREET, SUITE 2300 BOSTON MA 02110 1 0 0 0 Class A Common Stock 2022-06-01 4 A 0 21571 0.00 A 151639 D The restricted stock, granted pursuant to the Director Compensation Policy effective May 2019, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year. The total amount of shares beneficially owned has been adjusted to correct prior immaterial computational errors. /s/ Brian Tessler, Attorney-in-Fact 2022-06-03