X0306 4 2021-06-02 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001772130 Moukheibir Catherine C/O IRONWOOD PHARMACEUTICALS, INC. 100 SUMMER STREET, SUITE 2300 BOSTON MA 02110 1 0 0 0 Class A Common Stock 2021-06-02 4 A 0 22766 0.00 A 71760 D The restricted stock, granted pursuant to the Director Compensation Policy effective May 2019, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year. /s/ Brian Tessler, Attorney-in-Fact 2021-06-04