X0306 4 2021-02-24 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001570533 Owens Edward P C/O IRONWOOD PHARMACEUTICALS, INC. 100 SUMMER STREET, SUITE 2300 BOSTON MA 02110 1 0 0 0 Class A Common Stock 2021-02-24 4 P 0 7000 9.26 A 210954 D Class A Common Stock 2021-02-25 4 P 0 5000 9.11 A 215954 D Class A Common Stock 40000 I The Owens Family Foundation The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $9.19 to $9.31, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $9.05 to $9.16, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. The reporting person and certain members of his family are trustees of the foundation, the beneficial owner of the securities. The reporting person disclaims beneficial ownership of the securities. /s/ Brian Tessler, Attorney-in-Fact 2021-02-26