X0306 4 2019-05-29 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001570533 Owens Edward P C/O IRONWOOD PHARMACEUTICALS, INC. 301 BINNEY STREET CAMBRIDGE MA 02142 1 0 0 0 Class A Common Stock 2019-05-29 4 A 0 22706 0.00 A 182234 D Class A Common Stock 40000 I The Owens Family Foundation The restricted stock, granted pursuant to the director compensation policy, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year. The reporting person and certain members of his family are trustees of the foundation, the beneficial owner of the securities. The reporting person disclaims beneficial ownership of the securities. /s/ Conor Kilroy, Attorney-in-Fact 2019-05-31