Condensed Consolidated Statements of Cash Flows (USD $) In Thousands	6 Months Ended
Jun. 30, 2011	Jun. 30, 2010
Cash flows from operating activities:
Net loss	$ (37,245)	$ (33,462)
Loss from discontinued operations		(1,816)
Loss from continuing operations	(37,245)	(31,646)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	5,037	2,718
Loss on disposal of property and equipment		223
Share-based compensation expense	5,649	3,253
Accretion of discount/premium on investment securities	1,342	487
Changes in assets and liabilities:
Accounts receivable	268	621
Restricted cash	2,833	(2,348)
Prepaid expenses and other current assets	662	(1,253)
Other assets	60	(277)
Accounts payable and accrued expenses	1,571	425
Accrued research and development costs	(2,711)	(3,828)
Deferred revenue	(20,734)	(17,223)
Deferred rent	250	6,814
Other liabilities	897
Net cash used in operating activities from continuing operations	(42,121)	(42,034)
Net cash used in operating activities from discontinued operations		(2,443)
Total net cash used in operating activities	(42,121)	(44,477)
Cash flows from investing activities:
Purchases of available-for-sale securities	(57,082)	(274,131)
Sales and maturities of available-for-sale securities	106,586	37,467
Purchases of property and equipment	(5,467)	(8,604)
Net cash provided by (used in) investing activities from continuing operations	44,037	(245,268)
Net cash provided by investing activities from discontinued operations		1
Total net cash provided by (used in) investing activities	44,037	(245,267)
Cash flows from financing activities:
Proceeds from initial public offering		203,167
Proceeds from exercise of stock options, stock purchase plan and issuance of restricted stock	2,094	466
Payments on borrowings	(146)	(657)
Net cash provided by financing activities from continuing operations	1,948	202,976
Net cash used in financing activities from discontinued operations		(181)
Net cash provided by financing activities	1,948	202,795
Net increase (decrease) in cash and cash equivalents	3,864	(86,949)
Cash and cash equivalents, beginning of period	44,321	122,306
Cash and cash equivalents, end of period	48,185	35,357
Supplemental cash flow disclosures:
Cash paid for interest (including discontinued operations)	35	180
Purchases under capital leases	$ 325	$ 487

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The net change during the reporting period in the amount due that is the result of the cumulative difference between actual rent due and rental expense recognized on a straight-line basis.

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The increase during the period in capital lease obligations due to entering into new capital leases.

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The difference between the sale price or salvage price and the book value of a property, plant, and equipment asset that was sold or retired during the reporting period. This element refers to the gain (loss).

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This element represents the income or loss from continuing operations attributable to the economic entity which may also be defined as revenue less expenses and taxes from ongoing operations before extraordinary items, and noncontrolling interest.

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The net cash from (used in) all of the entity's operating activities, including those of discontinued operations, of the reporting entity. Operating activities generally involve producing and delivering goods and providing services. Operating activity cash flows include transactions, adjustments, and changes in value that are not defined as investing or financing activities. While for technical reasons this element has no balance attribute, the default assumption is a debit balance consistent with its label.

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The net cash from (used in) the entity's continuing operations. This element specifically EXCLUDES the cash flows derived by the entity from its discontinued operations, if any. This element is only to be used when the entity reports its cash flows attributable to discontinued operations separately from the cash flow provided by or used in operating activities. While for technical reasons this element has no balance attribute, the default assumption is a debit balance consistent with its label.

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- Definition

The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt.

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The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity.

+ References

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The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets.

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- Definition

The cash inflow associated with the amount received from entity's first offering of stock to the public.

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The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities.

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- Definition

The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

+ References

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