X0203 3 2010-02-02 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001117003 MCGUIRE TERRANCE C/O IRONWOOD PHARMACEUTICALS, INC. 320 BENT STREET CAMBRIDGE MA 02141 1 0 0 0 Class B Common Stock 40000 I By Bartlett Partners, LLC Class B Common Stock 163302 I By Polaris Venture Partners Founders' Fund II, L.P. Class B Common Stock 6100678 I By Polaris Venture Partners II, L.P. The Reporting Person is a manager of Bartlett Partners, LLC, the beneficial owner of the securities. The Reporting Person disclaims beneficial ownership of the securities, except to the extent of his pecuniary interest therein. The Reporting Person is a general partner of Polaris Venture Partners Founders' Fund II, L.P. and of Polaris Venture Partners II, L.P., the beneficial owners of the securities. The Reporting Person disclaims beneficial ownership of the securities, except to the extent of his pecuniary interest therein. Exhibit 24- Power of Attorney /s/Halley Gilbert, Attorney-in-Fact 2010-02-02