X0303 4 2010-08-02 1 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0000315066 FMR LLC 82 DEVONSHIRE STREET BOSTON MA 02109 0 0 1 1 Edward C. Johnson 3d FMR LLC is no longer subject to Section 16 based on updated information on Class A Common Stock outstanding provided by the issuer to the NASDAQ Stock Market on October 5, 2010. Scott C. Goebel, Duly authorized under Powers of Attorney effective as of June 1, 2008, by and on behalf of FMR LLC and its direct and indirect subsidiaries, and by and on behalf of Edward C. Johnson 3d 2010-11-04