X0306 4 2016-02-02 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001446372 Silva Paul M C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 SVP & Corp Controller Common Stock 2016-02-02 4 A 0 6875 0.01 A 21812 D Common Stock 2016-02-03 4 S 0 2300 89.96 D 19512 D Common Stock 2016-02-03 4 S 0 1900 91.07 D 17612 D Common Stock 2016-02-03 4 S 0 662 92.43 D 16950 D Common Stock 2016-02-03 4 S 0 200 93.06 D 16750 D Common Stock 169 I 401(k) Stock Option (Right to Buy) 91.05 2016-02-02 4 A 0 20625 0.00 A 2026-02-01 Common Stock 20625 20625 D Restricted stock grant vesting on 2/2/2019, subject to acceleration if certain financial and/or business metrics are achieved. Transaction made pursuant to Mr. Silva's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $89.96 (range $89.54 to $90.44). Mr. Silva undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $91.07 (range $90.56 to $91.48). Open market sales reported on this line occurred at a weighted average price of $92.43 (range $91.79 to $92.72). Open market sales reported on this line occurred at a weighted average price of $93.06 (range $92.98 to $93.14). The option vests in 16 quarterly installments from 02/02/2016. Omar White, Attorney-In-Fact 2016-02-04