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Note 6 - Stockholders' Equity, Stock Options and Warrants (Tables)
 9 Months Ended
Sep. 30, 2023
Notes Tables  
Share-Based Payment Arrangement, Activity [Table Text Block]
   

Stock Options

    

Warrants

  
   

Number of
Shares

    

Average
Exercise
Price

    

Number of
Shares

    

Average
Exercise
Price

  

Outstanding at December 31, 2021

     53,144     $ 96.60       1,584,995     $ 33.20  
                                 

Issued

     1,599       8.40       1,053,136       14.00  

Forfeited

     (2,013

)

     17.60       -       -  

Expired

     (3,677

)

     208.40       (5,422

)

     329.60  

Cancelled

     -       -       (816,272

)

     30.20  

Outstanding at December 31, 2022

     49,053     $ 91.69       1,816,437     $ 22.60  
                                 

Issued

     1,075       5.45       -       -  

Forfeited

     (49

)

     6.18       -       -  

Expired

     (1,854

)

     121.24       (9,417

)

     217.64  

Outstanding at September 30, 2023

     48,225     $ 83.58       1,807,020     $ 21.58