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Note 5 - Stockholders' Equity, Stock Options and Warrants (Tables)
3 Months Ended
Mar. 31, 2023
Notes Tables  
Share-Based Payment Arrangement, Activity [Table Text Block]
  

Stock Options

  

Warrants

 
  

Number of
Shares

  

Average
Exercise
Price

  

Number of
Shares

  

Average
Exercise
Price

 

Outstanding at December 31, 2021

  53,144  $96.60   1,584,995  $33.20 
                 

Issued

  1,599   8.40   1,053,136   14.00 

Forfeited

  (2,013

)

  17.60   -   - 

Expired

  (3,677

)

  208.40   (5,422

)

  329.60 

Cancelled

  -   -   (816,272

)

  30.20 

Outstanding at December 31, 2022

  49,053  $91.69   1,816,437  $22.60 
                 

Issued

  488   6.70   -   - 

Forfeited

  -   -   -   - 

Expired

  (1,736

)

  148.58   (4,058

)

  200.00 

Outstanding at March 31, 2023

  47,805  $84.88   1,812,379  $22.20