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Note 7 - Derivatives - Change in Fair Value of Derivative Liabilities (Details) - USD ($)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2021
Derivative liability balance $ 294,382 $ 50,989  
Derivative instrument recognized for May 2020 Warrants   294,382 $ 129,480
Reclassification of Warrant liabilities to Equity on exercise (1,701,756)    
Reclassification of Warrant liabilities to Equity (2,669,408)    
Gain recognized to revalue derivative instrument at fair value (164,902) (1,765,906)  
Derivative liability balance   $ 294,382  
A, B and Agent Warrants [Member]      
Derivative instrument recognized 2,669,995    
Promissory Note 2020 [Member]      
Derivative instrument recognized 120,921    
Warrants and Agent Warrants In Connection With May 2020 Warrant [Member]      
Derivative instrument recognized for May 2020 Warrants 1,324,184    
Derivative liability balance 1,324,184    
Warrants and Agent Warrants In Connection With June 2020 Warrant [Member]      
Derivative instrument recognized 495,100    
Derivative instrument recognized for May 2020 Warrants 1,749,721    
Derivative liability balance 1,749,721    
Promissory Note 2020 2 [Member]      
Derivative instrument recognized $ 20,542