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Note 7 - Derivatives (Details Textual)
3 Months Ended 12 Months Ended
Sep. 28, 2018
Mar. 31, 2020
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Mar. 01, 2021
USD ($)
Jun. 30, 2020
USD ($)
May 08, 2020
USD ($)
Mar. 18, 2020
USD ($)
Feb. 05, 2020
USD ($)
Dec. 31, 2019
USD ($)
Sep. 30, 2019
USD ($)
Dec. 31, 2018
USD ($)
Embedded Derivative, Gain (Loss) on Embedded Derivative, Net, Total       $ 50,989                
Derivative Liability, Total       0                
Embedded Derivative, Fair Value of Embedded Derivative Liability     $ 129,480             $ 294,382   $ 50,989
Gain (Loss) on Derivative Instruments, Net, Pretax, Total     164,902 1,765,907                
Promissory Note 2020 Conversion Feature, Tranche One [Member]                        
Embedded Derivative, Fair Value of Embedded Derivative Liability                 $ 68,796      
Promissory Note 2020 Conversion Feature, Tranche Two [Member]                        
Embedded Derivative, Fair Value of Embedded Derivative Liability                 52,125      
Promissory Note 2020 Conversion Feature, Tranche Three [Member]                        
Embedded Derivative, Fair Value of Embedded Derivative Liability                 $ 20,542      
Promissory Note 2020 Conversion Feature [Member]                        
Derivative Liability, Total     104,529 104,529 $ 0              
Derivative, Gain (Loss) on Derivative, Net, Total       87,923                
A, B and Agent Warrants [Member]                        
Derivative Liability, Total     41,336 33,654       $ 2,669,995        
Derivative, Gain (Loss) on Derivative, Net, Total     (7,683) 69,479                
A, B and Agent Warrants, Prior to Reclassification [Member]                        
Derivative, Gain (Loss) on Derivative, Net, Total   $ 700,910                    
Warrants and Agent Warrants In Connection With May 2020 Warrant [Member]                        
Derivative Liability, Total             $ 1,324,184          
Embedded Derivative, Fair Value of Embedded Derivative Liability       1,324,184                
Gain (Loss) on Derivative Instruments, Net, Pretax, Total       (460,065)                
Agent Warrants Issued In connection With May 2020 Offering [Member]                        
Derivative Liability, Total     33,819 42,646                
Derivative, Gain (Loss) on Derivative, Net, Total     (8,827)                  
Gain (Loss) on Derivative Instruments, Net, Pretax, Total       48,675                
Warrants and Agent Warrants In Connection With June 2020 Warrant [Member]                        
Derivative Liability, Total           $ 1,749,721            
Embedded Derivative, Fair Value of Embedded Derivative Liability       1,749,721                
Gain (Loss) on Derivative Instruments, Net, Pretax, Total       834,520                
Agent Warrants In Connection With June 2020 Warrant [Member]                        
Derivative Liability, Total     45,498 32,701                
Derivative, Gain (Loss) on Derivative, Net, Total     12,797                  
Gain (Loss) on Derivative Instruments, Net, Pretax, Total       79,045                
Promissory Note 2019 Conversion Feature [Member]                        
Derivative Liability, Total                     $ 495,100  
Promissory Note 2019 Conversion Feature Agent Warrants [Member]                        
Derivative Liability, Total       89,680 $ 0              
Derivative, Gain (Loss) on Derivative, Net, Total     $ 89,680                  
Gain (Loss) on Derivative Instruments, Net, Pretax, Total       $ 405,420                
Bridge Notes [Member] | Convertible Promissory Note [Member]                        
Debt Instrument, Convertible, Threshold Trading Days 20