Consolidated Statements of Stockholders' Equity - USD ($)	June 2020 Warrant [Member] Preferred Stock [Member] Series B Convertible Preferred Stock [Member]	June 2020 Warrant [Member] Preferred Stock [Member] Series D Convertible Preferred Stock [Member]	June 2020 Warrant [Member] Preferred Stock [Member] Series E Convertible Preferred Stock [Member]	June 2020 Warrant [Member] Common Stock [Member]	June 2020 Warrant [Member] Additional Paid-in Capital [Member]	June 2020 Warrant [Member] Retained Earnings [Member]	June 2020 Warrant [Member]	Warrants Issued Pursuant to 2020 Convertible Debt [Member] Additional Paid-in Capital [Member]	Warrants Issued Pursuant to 2020 Convertible Debt [Member]	Warrants Issued Pursuant to 2020 Convertible Debt 2 [Member] Additional Paid-in Capital [Member]	Warrants Issued Pursuant to 2020 Convertible Debt 2 [Member]	Prefunded Warrants [Member] Common Stock [Member]	Prefunded Warrants [Member] Additional Paid-in Capital [Member]	Prefunded Warrants [Member]	Preferred Stock [Member] Series B Convertible Preferred Stock [Member] Registered Direct Offerings [Member]	Preferred Stock [Member] Series B Convertible Preferred Stock [Member] Private Placement [Member]	Preferred Stock [Member] Series B Convertible Preferred Stock [Member] June 2021 Offering [Member]	Preferred Stock [Member] Series B Convertible Preferred Stock [Member]	Preferred Stock [Member] Series D Convertible Preferred Stock [Member] Conversion of Series D Preferred Stock to Common Stock [Member]	Preferred Stock [Member] Series D Convertible Preferred Stock [Member]	Preferred Stock [Member] Series E Convertible Preferred Stock [Member] Series E Preferred Stock Conversions [Member]	Preferred Stock [Member] Series E Convertible Preferred Stock [Member]	Common Stock [Member] Registered Direct Offerings [Member]	Common Stock [Member] Private Placement [Member]	Common Stock [Member] June 2021 Offering [Member]	Common Stock [Member] May 2020 Offering [Member]	Common Stock [Member] Bridge Notes [Member]	Common Stock [Member] Series E Preferred Stock Conversions [Member]	Common Stock [Member] Conversion of Series D Preferred Stock to Common Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member] Registered Direct Offerings [Member]	Additional Paid-in Capital [Member] Private Placement [Member]	Additional Paid-in Capital [Member] June 2021 Offering [Member]	Additional Paid-in Capital [Member] May 2020 Offering [Member]	Additional Paid-in Capital [Member] Bridge Notes [Member]	Additional Paid-in Capital [Member] Series E Preferred Stock Conversions [Member]	Additional Paid-in Capital [Member] Conversion of Series D Preferred Stock to Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member] Registered Direct Offerings [Member]	Retained Earnings [Member] Private Placement [Member]	Retained Earnings [Member] June 2021 Offering [Member]	Retained Earnings [Member]	Registered Direct Offerings [Member]	Private Placement [Member]	June 2021 Offering [Member]	May 2020 Offering [Member]	Bridge Notes [Member]	Total
Balance (in shares) at Dec. 31, 2019																		79,246		3,500,000		258								4,056,652
Balance at Dec. 31, 2019																		$ 792		$ 35,000		$ 3								$ 40,567								$ 93,653,667				$ (82,498,711)						$ 11,231,318
Shares issued pursuant to CEO note conversion and accrued interest and exchange agreement (in shares)																														1,583,481
Shares issued pursuant to CEO note conversion and accrued interest and exchange agreement																														$ 15,835								2,307,043										2,322,878
Inducement shares issued pursuant to promissory note extension (in shares)																														30,000
Inducement shares issued pursuant to promissory note extension																														$ 300								40,950										41,250
Issuance of shares and prefunded warrants pursuant to March 2020 private placement (in shares)																														260,000
Issuance of shares and prefunded warrants pursuant to March 2020 private placement																														$ 2,600								455,223										457,823
Inducement shares issued pursuant to 2020 convertible debt and warrants (in shares)																														46,875
Inducement shares issued pursuant to 2020 convertible debt and warrants																														$ 468								119,532										120,000
Warrants issued pursuant to 2020 convertible debt								$ 116,951	$ 116,951	$ 62,373	$ 62,373
Shares issued pursuant to conversions (in shares)																			(3,500,000)		(258)						170,000	1,398,607	350,004	2,212,359
Shares issued pursuant to conversions																			$ (35,000)		$ (3)						$ 1,700	$ 13,986	$ 3,500	$ 22,124					$ 265,628	$ (13,983)	$ 31,500	1,006,230									$ 267,328	1,028,354
Issuance of shares from prefunded warrant exercises (in shares)				1,274,826								1,390,166																		122,000
Issuance of shares from prefunded warrant exercises				$ 12,748	$ 1,682,237		$ 1,694,985					$ 13,902	$ (13,149)	$ 753																$ 1,220								190,930										192,150
Shares issued (in shares)																										1,396,826
Issuance of shares																										$ 13,968								$ 591,949												$ 605,917
Shares issued in connection with asset purchase agreement (in shares)																														1,079,719
Shares issued in connection with asset purchase agreement																														$ 10,797								1,661,970										1,672,767
Repricing and Reclassification of warrants issued pursuant to convertible debt					$ 803,455		$ 803,455																															1,865,953										1,865,953
Shares issued pursuant to Equity Line (in shares)																														4,231,073
Shares issued pursuant to Equity Line																														$ 42,311								4,849,037										4,891,348
Share issuance to consultant and other (in shares)																														202,199
Share issuance to consultant and other																														$ 2,022								428,184										430,206
Vesting expense and option repricing																																						721,269										721,269
Net loss																																										(25,884,397)						(25,884,397)
Balance (in shares) at Dec. 31, 2020																		79,246		0		0								19,804,787
Balance at Dec. 31, 2020																		$ 792		$ 0		$ 0								$ 198,048								110,826,949				(108,383,108)						2,642,681
Shares issued pursuant to CEO note conversion and accrued interest and exchange agreement (in shares)																														400,000
Shares issued pursuant to CEO note conversion and accrued interest and exchange agreement																														$ 4,000								(4,000)										0
Shares issued pursuant to conversions (in shares)																														1,107,544
Shares issued pursuant to conversions																														$ 11,075								502,936										514,011
Issuance of shares from prefunded warrant exercises (in shares)																														5,269,059
Issuance of shares from prefunded warrant exercises																														$ 52,702								4,461,169										4,513,871
Shares issued (in shares)																							13,488,098	9,043,766	15,520,911
Issuance of shares																							$ 134,881	$ 90,438	$ 155,209						$ 14,877,611	$ 15,974,301	$ 19,291,087										$ 15,012,492	$ 16,064,739	$ 19,446,296
Shares issued pursuant to Equity Line (in shares)																														647,504
Shares issued pursuant to Equity Line																														$ 6,475								669,115										675,590
Share issuance to consultant and other (in shares)																														174,954
Net loss																														$ 0								0				(19,657,174)						(19,657,174)
Balance (in shares) at Dec. 31, 2021																		79,246												65,614,597
Balance at Dec. 31, 2021																		$ 792												$ 656,146								167,649,028				(128,040,282)						40,265,684
Shares issued pursuant to agreement with former CEO related to accrued interest (in shares)																														100,401
Shares issued pursuant to agreement with former CEO related to accrued interest																														$ 1,004								142,569										143,573
Share issuance to consultant and other																														$ 1,750								203,443										205,193
Vesting expense and option repricing (in shares)																														57,573
Vesting expense and option repricing																														$ 564								$ 703,848										$ 704,412